Publications

1. Brown, D. R., C. M. Koehler, G. L. Lindberg, A. E. Freeman, J. E. Mayfield, A. M. Myers, M. M. Schutz, and D. C. Beitz. 1989. Molecular analysis of cytoplasmic genetic variation in Holstein cows. J. Anim. Sci. 67:1926-1932. [Pubmed link]

2. Lindberg, G. L., B. B. Shank, M. F. Rothschild, J. E. Mayfield, A. E. Freeman, C. M. Koehler, and D. C. Beitz. 1989. Characteristics of mammary mitochondria in lines of mice genetically divergent for milk production. J. Dairy Sci. 72:1175-1181. [Pubmed link]

3. Koehler, C. M., G. L. Lindberg, D. R. Brown, D. C. Beitz, A. E. Freeman, J. E. Mayfield, and A. M. Myers. 1991. Replacement of bovine mitochondrial DNA by a sequence variant within a single generation. Genetics 129:247-255. [Pubmed link]

4. Lindberg, G.L., C. M. Koehler, J. E. Mayfield, A. M. Myers, and D. C. Beitz. 1992. Recovery of mitochondrial DNA from blood leukocytes using detergent lysis. Biochem. Genet. 27-33. [Pubmed link]

5. Blacketer, M. J., C. M. Koehler, S. G. Coats, A. M. Myers, and P. M. Madaule. 1993. Regulation of dimorphism in Saccharomyces cerevisiae: Involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A. Mol. Cell. Biol. 13:5567-5581. [Pubmed link]

6. Schutz, M. M., A. E. Freeman, G. L. Lindberg, C. M. Koehler, and D. C. Beitz. 1994. The effect of mitochondrial DNA on milk production and health of dairy cattle. Livest. Prod. Sci. 37:283-295. [Pubmed link]

7. Koehler, C. M., and A. M. Myers. 1997. Serine-threonine protein kinase activity of Elm1p a regulator of morphologic differentiation in Saccharomyces cerevisiae. FEBS Lett. 408:109-114. [Pubmed link]

8. Koehler, C. M., E. Jarosch, K. Tokatlidis, K. Schmid, R. J. Schweyen, and G. Schatz. 1998. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science 279:369-373. [Pubmed link]

9. Komiya, T., S. Rospert, C. M. Koehler, R. Looser, G. Schatz, and K. Mihara. 1998. Interaction of mitochondrial targeting signals with acidic receptor domains along the protein import pathway: Evidence for the "acid chain" hypothesis. EMBO J. 17: 3886-3898. [Pubmed link]

10. Koehler, C. M., S. Merchant, W. Oppliger, K. Schmid, E. Jarosch, L. Dolfini, T. Junne, G. Schatz, and K. Tokatlidis. 1998. Tim9p, an essential partner of Tim10p for the import of mitochondrial carriers. EMBO J, 17:6477-6486. [Pubmed link]

11. Koehler, C. M., D. Leuenberger, S. Merchant, A. Renold, T. Junne, and G. Schatz. 1999. Human deafness dystonia syndrome is a mitochondrial disease. Proc. Natl. Acad. Sci. (USA) 96:2141-2146. [Pubmed link]

12. Koehler, C. M., S. Merchant, and G. Schatz. 1999. How membrane proteins travel across the mitochondrial intermembrane space. Trends Biochem. Sci. 24:428-432. [Pubmed link]

13. Leuenberger, D., N. Bally, G. Schatz, and C. M. Koehler. 1999. Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J. 18:4816-4822. [Pubmed link]

14. Renold, A., C. M. Koehler, and M. P. Murphy. 2000. Mitochondrial import of the long and short isoforms of human uncoupling protein 3. FEBS Lett. 465:135-140. [Pubmed link]

15. Koehler, C. M., M. P. Murphy, N. A. Bally, D. Leuenberger, W. Oppliger, L. Dolfini, T. Junne, G. Schatz, and E. Or. 2000. Tim18p, a novel subunit of the mitochondrial inner membrane complex that mediates import of inner membrane proteins. Mol. Cell. Biol 20:1187-1193. [Pubmed link]

16. Dyall, S. M., C. M. Koehler, M. G. Delgadillo, P. J. Bradley, E. Plümper, D. Leuenberger, C. W. Turck, and P. J. Johnson. 2000. The presence of mitochondria carrier in the hydrogenosomal membranes: conservation of membrane targeting pathways indicated a progenitor organelle gave rise to hydrogenosomes and mitochondria. Mol. Cell. Biol. 20:2488-2497. [Pubmed link]

17. Patterson, S. D., C. S. Spahr, E. Daugas, S. A. Susin, T. Irinopoulou, C. Koehler, and G. Kroemer. 2000. Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition. Cell Death Differ. 7:137-144. [Pubmed link]

18. C. M. Koehler. 2000. Protein translocation pathways of the mitochondrion. FEBS Lett. 476:27-31. [Pubmed link]

19. Murphy, M. P., D. Leuenberger, S. P. Curran, W. Oppliger, and C. M. Koehler. 2001. The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex. Mol. Cell. Biol. 21:6132-6138. [Pubmed link]

20. Roesch, K., S. P. Curran, L. Tranebjaerg, and C. M. Koehler. 2002. Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. Hum. Mol. Genet. 11:477-486. [Pubmed link]

21. Curran, S. P., D. Leuenberger, W. Oppliger, and C. M. Koehler. 2002. The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. EMBO J. 21:942-953. [Pubmed link]

22. Curran, S. P., D. Leuenberger, E. Schmidt, and C. M. Koehler. 2002. The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J. Cell Biol. 158:1017-1027. [Pubmed link]

23. Roesch, K., L. Tranebjaerg, and C. M. Koehler. 2002. How do defects in mitochondrial protein import lead to deafness. In Tranbjaerg, L., Christensen-Dalsgaard, J., Andersen, T. and Poulsen, T. (eds.), 19th Danavox Symposium: Genetics and the function of the auditory system. Homens Trykkeri, Kolding, Denmark, Vol. 19, pp. 139-154. [Pubmed link]

24. Leuenberger, D., S. P. Curran, D. Wong, and C. M. Koehler. 2003. The role of Tim9p in assembly of the TIM22 import complexes. Traffic 4:144-152. [Pubmed link]

25. Koehler, C. M. 2003. Import and assembly. In Holt, I. (ed.) Genetics of Mitochondrial Diseases. Oxford University Press, Oxford, pp. 47-68. [Pubmed link]

26. Dyall, S.D., D. C. Lester, R. E. Schneider, M. G. Delgadillo-Correa, E. Plumper, A. Martinez, C. M. Koehler, and P. J. Johnson. 2003. Trichomonas vaginalis Hmp35, a putative pore-forming hydrogenosomal membrane protein, can form a complex in yeast mitochondria. J. Biol. Chem. 278:30548-30461. [Pubmed link]

27. van der Bliek, A. M., and C. M. Koehler. 2003. A mitochondrial rhomboid protease. Dev. Cell. 4:769-770. [Pubmed link]

28. Leuenberger, D., S. P. Curran, and C. M. Koehler. 2004. Structure, bioenergetics, and biogenesis of mitochondria. In Mullins, C. (ed.) The Biogenesis of Cellular Organelles. Landes Bioscience, Georgetown, pp138-163. [Pubmed link]

29. Koehler, C. M. 2004. The small Tim proteins and the twin CX3C motif. Trends Biochem. Sci.1:1-4. [Pubmed link]

30. Roesch, K., P. H. Hynds, R. Varga, L. Tranebjaerg, and C. M. Koehler. 2004. The calcium-binding apartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex. Hum. Mol. Genet. 13:2101-2111. [Pubmed link]

31. Curran, S. P., D. Leuenberger, E. P. Leverich, D. K. Hwang, K. N. Beverly, and C. M. Koehler. 2004. The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. J. Biol. Chem. 279:43744-43751. [Pubmed link]

32. Curran, S. P. and Koehler, C. M. 2004. Mitochondrial biogenesis. Protein import into and across the inner membrane. In Koehler, C.M. and Bauer, M.F. (eds.), Topics in Current Genetics: Mitochondrial Function and Biogenesis. Springer-Verlag, Heidelberg, Vol. 8, pp. 59-80. [Pubmed link]

33. Koehler, C. M. 2004. New developments in mitochondrial assembly. Ann. Rev. Cell. Dev. Biol. 20:309-335. [Pubmed link]

34. Curran, S. P., E. P. Leverich, C. M. Koehler, and P. L. Larsen. 2004. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. J. Biol. Chem. 279:54655-54662. [Pubmed link]

35. Likic V. A., A. Perry, J. Hulett, M. Derby, A. Traven, R. F. Waller, P. J. Keeling, C. M. Koehler, S. P. Curran, P. R. Gooley, and T. Lithgow. 2005. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. J. Mol. Biol. 347:81-93. [Pubmed link]

36. Koehler, C. M. and D. K. Hwang. 2005. Protein translocation across membranes. In Meyers, R. A. (ed.), Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-VCH, Weinheim, Vol. 11, pp. 287-308.

37. Claypool, S. M. and C. M. Koehler. 2005. Hereditary Spastic Paraplegia: respiratory choke or unactivated substrate? Cell 123:183-185. [Pubmed link]

38. Koehler, C. M., K. N. Beverly, and E. P. Leverich. 2006. Redox Pathways of the Mitochondrion. Antioxid. Redox Signal. 8:813-822.

39. Claypool, S. M., J. M. McCaffery, and C. M. Koehler. 2006. Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. J. Cell Biol. 174:379-390. [Pubmed link]

40. Chen H.-W., R. N. Rainey, C. E. Balatoni, D. W. Dawson, J. J. Troke, S. Wasiak, J. Hong, H. Mcbride, C. M. Koehler, M. A. Teitell, and S. W. French.. 2006. Mammalian PNPase is an intermembrane space ribonuclease that maintains mitochondrial homeostasis. Mol. Cell. Biol. 26:8475-8487. [Pubmed link]

41. Rainey, R. N., J. D. Glavin, H.-W. Chen, S. W. French, M. A. Teitell, and C. M. Koehler, 2006. A new function in translocation for the mitochondrial i-AAA protease Yme1: Import of PNPase into the intermembrane space. Mol. Cell. Biol. 26:8488-8497. [Pubmed link]

42. French, S. W., D. W. Dawson, H.-W. Chen, R. N. Rainey, S. A. Sievers, C. E. Balatoni, L. Wong, J. J. Troke, M. T. N. Nguyen, C. M. Koehler, and M. A. Teitell. 2007. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. Cancer Lett. 248:198-210. [Pubmed link]

43. Stuart, R. A. and C. M. Koehler. 2007. In Vitro Analysis of Yeast Mitochondrial Protein Import. In Morgan, K. (ed.) Current Protocols in Cell Biology 11.19.1-11.19.20.

44. Lu, G., S. Ren, P. Korge, J, Choi, Y. Dong, J. Weiss, C. Koehler, J.N. Chen, and Y. Wang. 2007. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 21:784-796. [Pubmed link]

45. Hwang, D. K., S. M. Claypool, H. D. Tienson, D. Leuenberger, and C. M. Koehler. 2007. Tim54p mediates assembly of the i-AAA protease Yme1p. J. Cell Biol.178:1161-75. [Pubmed link]

46. Oktay, Y., R. N. Rainey, and C. M. Koehler. 2007. The function of TIM22 in the insertion of inner membrane proteins in mitochondria. In Dalbey, R. E., Koehler, C. M., and Tamanoi, F. (eds.) The Enzymes: Molecular Machines Involved in Protein Trasnport across Membrane. 25:367-386.

47. Sediva, A., C. I. E. Smith, A. C. Asplund, J. Hadac, A. Janda, J. Zeman, H. Hansikova; L. Dvorakova, L. Mrazova, S. Velbri, C. Koehler, K. Roesch, K. E. Sullivan, T. Futatani, and H. Ochs. 2007. Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L and DRP2 genes. J. Clin. Immunol. In Press. [Pubmed link]

48. Dabir, D. V., E. P. Leverich, S.-K. Kim, F. D. Tsai, M. Hirasawa, D. B. Knaff, and C. M. Koehler. 2007. A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1. EMBO J. In Press. [Pubmed link]

editied books

1. Koehler, C.M. and Bauer, M.F. (eds.), Topics in Current Genetics: Mitochondrial Function and Biogenesis. Springer-Verlag, Heidelberg, Vol. 8, pp. 333.

2. Dalbey, R. E., Koehler, C. M., and Tamanoi, F. (eds.) The Enzymes: Molecular Machines Involved in Protein Trasnport across Membranes. Elsevier, Oxford, Vol. 25, pp.635.

bottom corner